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While physical inactivity is a growing problem among all populations in the United States, transgender and gender-diverse (TGD) individuals experience stigma, discrimination, and other additional barriers to being physically active. Recent literature suggests that TGD individuals engage in much less physical activity than cisgendered individuals, with transgender women reporting the lowest levels of physical activity among all genders. This policy statement recommends several interventions to support TGD individuals’ engagement in physical activity. It calls on existing organizations that implement physical activity programs to create TGD-inclusive policies. Researchers need to develop and implement evidence-based TGD-specific interventions, especially for TGD adults. In addition, federal agencies that promote physical activity must create TGD-specific materials as they have for other populations experiencing limited engagement in physical activity.